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Mutations in these regions can disturb GTP binding and lead to decreased sensitivity of GDH to allosteric regulation by GTP, resulting in weakened inhibitory effect and enhanced GDH activity [12]

BCAAs metabolism is altered in various tumors such as PDAC, NSCLC, BRCA, GBM, etc

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Bolouki, A., Zal, F

Janku F, Huang HJ, Fujii T, Shelton DN, Madwani K, Fu S, Tsimberidou AM, Piha-Paul SA, Wheler JJ, Zinner RG, Naing A, Hong DS, Karp DD, Cabrilo G, Kopetz ES , Subbiah V, Luthra R, Kee BK, Eng C, Morris VK, Karlin-Neumann GA, Meric-Bernstam F

Cellular Repair DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome ( genetic material of an organism)