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Secondly, NPT ensemble equilibration (constant particle number, pressure, and temperature) followed with a 100 ps simulation at 1 bar, aiming to enable the system to adapt to the specified pressure, thereby stabilizing the density of the system

When the extent of such injury overwhelms DNA repair capacity mechanisms, the subsequent alterations in mitochondrial biology stimulate the activation of the genes responsible for stressresponse, hereby inducing apoptosis [116]

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