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The authors acknowledge this limitation

Yin Y, Li D, Liu F, Wang X, Cui Y, Li S, et al

This is the central reason microinfusion outperforms solid-needle microneedling for the four hero molecules

This interaction is mediated by dual binding, with FHD mainly binding to the p53 TAD and FOXO4 CR3 binding to the p53 DNA-binding domain (DBD) 38 (Figure