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Towards synthetic viruses

At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling (178180)

Essential strategies to manage oxidative stress include: Reduce Toxic Burden : Environmental exposure to toxins, heavy metals, pollutants, and industrial chemicals can trigger oxidative stress by catalyzing ROS production, promoting free radical production, depleting antioxidants, and inhibiting their protective functions

Groen EJ, Roos A, Muntinghe FL, et al.: Extra-intestinal manifestations of familial adenomatous polyposis

An essential role for phoP in Mycobacterium tuberculosis virulence

Pinnix ZK, Miller LD, Wang W, et al