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Independent replication of lifespan data outside Khavinson's laboratory

Calautti E, Avalle L, Poli V

The accumulation of AGEs is widely recognized as a hallmark of aging, particularly in skin tissue, where protein cross-linking compromises collagen integrity and elasticity while excessive reactive oxygen species (ROS) generation accelerates tissue damage 35,36,37

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Hu C, Gao S, Li X, Yang K, Cheng Y, Guo W et al (2025) Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy