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In a study done in 15 patients with PD, 200 mg of GSH was given intranasally and showed that GSH levels did not only raise, but the levels remained high even 1 hour after administration

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Gastrointestinal agents: While yet controversial and difficult to assess, many studies point to an increased incidence of gastrointestinal issues (such as chronic diarrhea, constipation, or acid reflux disease) in individuals with ASD

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In addition, deletion of the GSH1 geneencoding -glutamylcysteine synthetase (-GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)