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Later, the same research team found that keratinocyte-specific knockout mice lacking GPX4 showed aberrant epidermis proliferation, infiltration of inflammatory cells in the dermis, and morphologic alteration of hair follicles

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Iron, an essential trace element for the human body, is involved in numerous physiological functions such as erythropoiesis, energy metabolism, muscle function and cell cycle regulation (19)

5.2.4 Autophagy and oxidative stress Autophagy and oxidative stress are reciprocally regulated in MAFLD, and their crosstalk drives hepatocellular metabolic injury and inflammatory activation

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