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Pinna, The novel rapid-acting neurosteroid-based antidepressant generation

Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling

An injection is quick to administer and quickly addresses deficiencies

doi: 10.1073/pnas.0511232103

An acquired deficiency in glutathione, as with alcohol or paracetamol, results in loss of this negative feedback and increased production of 5-oxoproline leading to a metabolic acidosis