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AMPK, a modulator of autophagy, elicits its actions through the activation of SIRT-1 to enhance autophagy and halt apoptosis (Meijer and Codogno 2007)

In some embodiments, non-hydrogen substituent includes methyl

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Gaede L, Liebetrau C, Blumenstein J, Troidl C, Drr O, Kim WK, et al

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We next attempted to rescue mitochondrial oxidative phosphorylation and glycolysis by co-supplementation with antioxidants, both cell-wide (2.5 mM GSH and 25 M Trolox) and mitochondrial-targeted [10 nM mitoquinol (MQ) and 1 nM SKQ1] (22, 23)

Correspondingly, the inhibition of NF-B by BAY 11-7082 significantly increased the survived SGN numbers, while decreased the C-CASP3 positive SGN numbers and the C-CASP3 expression in peroxynitrite + BAY 11-7082 group compared with the peroxynitrite group (Figures 9DF)