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2.2.2 Reduction of the mitochondrial dysfunction and oxidative stress impact Mitochondrial dysfunction plays a crucial role in the pathophysiology of glaucoma by disrupting oxidative phosphorylation and increasing the production of reactive oxygen species (ROS)

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Ruan, Q., Wang, C., Zhang, Y

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Iron metabolism disorder, lipid peroxidation and decreased antioxidant capacity are involved in the occurrence of ferroptosis, and several key regulators (e.g., system Xc - , GPX4, p53 and ACSL4) play an important role in monitoring ferroptosis