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Additionally, ROS activates stress-sensitive kinases (JNK, p38 MAPK) that phosphorylate IRS-2, accelerating its proteasomal degradation and further impairing -cell survival (Liu et al., 2020)

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doi: 10.1111/bjd.17695 34

doi: 10.1016/s1097-2765(02)00445-8 17 BrownleeM

In addition, to increase corneal passing of N-acetylcarnosine, this prodrug has been also loaded in gold nanoparticles with good results in terms of biosafety and bioavailability [80]