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A pilot study has been performed on 28 patients (23 males and five females) to evaluate the efficiency of curcumin in decreasing TGF- levels

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Andreeff M , Zhao S, Xie Z, Konopleva M, Estey E, Munsell M, Sanchez-Williams G, Kornblau S, Reed J

In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)

10.1023/A:1005814109732 Summary Keywords reactive oxygen species, abiotic stress, redox homeostasis, ascorbate-glutathione pathway, isoforms, gene families Citation Pandey P, Singh J, Achary VMM and Reddy MK (2015) Redox homeostasis via gene families of ascorbate-glutathione pathway

Proton magnetic resonance spectroscopy studies have demonstrated a significantly higher Gln/Glu ratio in the anterior cingulate cortex and parieto-occipital cortices of patients with bipolar disorders in maniac episodes compared to healthy subjects (ngr et al., 2008)