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Researchers have demonstrated that amino acid metabolism is related to ferroptosis and that CCH can cause neuronal depolarization to release excess glutamate during the pathogenesis of VD, resulting in excitotoxicity, and high levels of glutamate inhibit the function of System Xc-

15, 7642 (2025), Abstract A sesquiterpene lactone, tomentosin, as a novel anticancer agent: orchestrating apoptosis, autophagy, and ER stress in colorectal cancer: S

Supporting the translational relevance of our findings, analysis of publicly available transcriptomic datasets (GEO: GSM8328845 and GSM5557972) revealed a consistent trend toward increased MLKL expression in human AAA tissue (Supplementary Fig

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Another significant macrophage kinase that can induce pro-inflammatory macrophage polarisation is Bruton's tyrosine kinase (BTK)

Banerjee et al., 2021)