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Among genetic predispositions, specific human leukocyte antigen (HLA) genes are strongly implicated, such as HLA-B51 in BD ( Figure 1 ) ( Figure 1 Based on current evidence, we hypothesize that dysbiosis of the gut microbiome and its metabolites trigger gut inflammation and increase intestinal permeability (leaky gut)

Consuming excessive amounts of acetaminophen, particularly in combination with alcohol, can overwhelm the liver's ability to metabolize both substances effectively, increasing the risk of liver toxicity

Acknowledgements We thank Kevin Vogt for helpful assistance in the preparation of this manuscript

In addition, metabolic alterations in Ssu72-deleted WAT are reversed by restoring Ssu72 expression

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The reference electrode was placed 34 mm subdermally above the ankle near the tendons