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Schwartzberg 2014)

He may also seem restless, anxious and twitching his tail more than usual

This homeostatic behavior of Hcy is intriguing: It runs counter to the clinical observation that vitamin B 12 deficiency results in hyperhomocysteinemia

and ACSL4, ALOX12 and ALOX15, which are involved in lipid oxidation, are all known targets for driving ferroptosis

Reactive astrocytes exacerbate inflammation by releasing additional cytokines, contributing to a feedback loop that worsens neuronal injury ( The interaction between excitotoxicity and neuroinflammation is critical for the development of long-term neurodegeneration