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J Am Coll Surg 235(1):8-16, 2022

Furthermore, expression of tissue inhibitors of metalloproteinases (TIMPs) is increased by myofibroblasts, leading to reduced extracellular matrix degradation [257, 258]

The net result of these processes is an increase in serum concentrations, which, by the way, has been demonstrated to escalate the risk and/or severity of ADRs associated to exposure to such drugs (DrugBank Clinical API Plugins, 2024)

564 Furthermore, zinc released from corticostriatal terminals may predominantly contribute to the deleterious effects associated with motor and cognitive symptoms in PD, as it acts synergistically with glutamate