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These results strongly imply that treatment with KRAS (G12C) inhibitors triggers the release of ERK-mediated feedback inhibition, which reactivates KRAS signalling in turn to confer therapeutic resistance

One study elucidated a link between mutations in optineurin with pathology of primary open-angle glaucoma, emphasizing evidence of impaired mitophagy leading to the accumulation of damaged mitochondria (Shim et al., 2016)

Serine metabolism, especially the de novo serine synthesis pathway, forms a metabolic network with glycolysis, folate cycle, and one-carbon metabolism, which is essential for rapidly proliferating cells

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Materials and methods: EVs were isolated from patient plasma samples by ultracentrifugation in combination with SEC-based column purification