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Disrupting this machinery is associated with the loss of ETC function and an increase in ROS production 36,37

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10.1074/jbc.RA119.009548 115 NunomuraA.MoreiraP

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ALT: alanine transaminase AST: aspartate transaminase DMT1: divalent metal transporter 1 RBC: red blood cell count FAC: ferric citrate FTH/L: ferritin heavy/light chain Fpn: ferroportin GSH: glutathione GSSG: glutathione, Oxydized GPX4: glutathione peroxidase 4 HGB: hemoglobin HCT: hematocrit HO-1: heme oxygenase 1 MCV: mean corpuscular volume MCH: mean corpuscular hemoglobin MCHC: mean corpuscular hemoglobin concentration MDA: malondialdehyde NOQ1: quinone oxidoreductase 1 Ptgs2: Prostaglandin G/H synthase 2 ROS: reactive oxygen species SLC3A2: solute carrier family 3 member 2 SLC7A11: solute carrier family 7 member 11 TF: transferrin saturation TIBC: total iron binding capacity TfR1: transferrin receptor 1 UIBC: unsaturated iron binding capacity The authors have declared that no competing interest exists