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This enzyme wastes a helpful molecule called nicotinamide (a form of vitamin B3) by turning it into something useless instead of recycling it into NAD+, think of NAD+ as the main battery fuel that powers your cells energy factories (mitochondria)

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Together with folate, cobalamins are essential cofactors required for DNA synthesis in cells where chromosomal replication and division are occurringmost notably the bone marrow and myeloid cells