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Their origin is debated and has been ascribed variably at resident fibroblasts, at circulating fibrocytes (cells of hematopoietic origin with mesenchymal properties including the capacity to produce collagen), at smooth muscle cells, at epithelial cells undergoing mesenchymal transition, or similarly at endothelial cells undergoing mesenchymal transition (Fig

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Thus, MDA and 4-HNE are considered effective biomarkers for reflecting the progression of OA (Shah et al., 2005

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Fan S, Chang JK, Smith ML, Duba D, Fornace Jr AJ and O'Connor PM