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Inui, 2001), with both increasing AMP-activated protein kinase (AMPK) activity in the hypothalamus and reducing it in the liver and adipose tissue (Kola et al., 2005)

Co-crystal technologies utilize multi-component crystalline materials formed through non-covalent interactions between bioactive compounds and Generally Recognized as Safe (GRAS) co-formers (235)

Taken together, Nrf2 activators are thought to protect kidneys from oxidative damage via induction of antioxidant genes and prevention of Epo deficiency by intervening in the negative spiral consisting of oxidative stress and tubular damage (Figure 4A)

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