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Description

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

While each component ideally represents an in-focus neuronal soma, the identification process also captures confounding components which can arise from out-of-focus somata, non-somatic structures (e.g., dendrites or blood vessels), or non-biological sources (e.g., fluctuations in background fluorescence), all of which are considered abnormal signals or artifacts