glutathione literature Glutathione: Biosynthesis, Functions and Biological Implications Glutathione: Dietary Sources, Role in

Materials and Methods GSH/GSSG-Glo Assay (Cat.# V6611) CellTox Green Cytotoxicity Assay (Cat.# G8741) menadione (Sigma, Cat.# M5625) l-Buthionine Sulfoximine (Sigma, Cat.# B2515) digitonin (Sigma, Cat.# D141) HEK-293 cells K-562 cells Note: Cell lines were authenticated using STR genotyping ( GenePrint 10 System, Cat.# B9510)

In addition, gadolinium may enter soil and groundwater through agricultural use of mineral (e.g., Changle and Nongle) or organic (sewage sludge) fertilizers or the disposal of waste in landfills (Figure 2) [10,24,40,41]

Sig Transduct Target Ther 9 , 271 (2024)

145 YehoshuaZ.de Amorim Garcia, FilhoC

Following these promising preclinical results, the addition of slow-release niacin (niacin CRT ) to standard of care entered a Phase I/IIa clinical trial in individuals with GBM (clinicaltrials.gov NCT04677049) (Table 1)

k , Immunoblot of SLC25A39 and ATF4 proteins in HeLa cells treated with indicated doses of mitoCDNB, diamide and BSO (1 mM)/erastin (5 M) for 24 h