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2a and Supplementary Table 1, parent K D = 5 nM)

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The lower concentration allows for more precise dosing at lower doses during the titration phase

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Key Mechanistic Differences# The mechanistic distinction is significant: Dihexa promotes structural synaptic plasticity through growth factor signaling (building new connections), while PE-22-28 modulates functional neuronal properties through ion channel blockade (changing how existing neurons fire)