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2014;24(2):e86-94

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Timeline varies with injury severity, age, and adherence to the protocol your provider sets

At each stenosis, we simulated 4 situations: no catheter/pressure wire insertion (in vivo status), catheter inserted proximally to ICAS without pressure wire, catheter inserted and pressure sensor placed at 1cm&2cm distally to ICAS lesion

When activated, the IRR initiates several critical cytoprotective cascades: JAK2/STAT3 and STAT5 signalling promoting anti-apoptotic gene expression and cellular survival PI3K/Akt pathway suppressing pro-apoptotic factors and promoting neuronal and endothelial cell survival NF-B modulation reducing pro-inflammatory cytokine production including TNF-, IL-1, and IL-6 MAPK/ERK activation supporting cellular repair and adaptive stress responses Anti-oxidant pathway upregulation reducing oxidative damage in metabolically stressed cells ARA-290s selective activation of the IRR without EPOR homodimer engagement allows researchers to study all of the above pathways without the erythropoietic confound present in full-length EPO studies