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doi:10.1080/00365513.2020.1804610 Kanth VV, Golla JP, Sastry BK, et al

To determine whether increased hepatocyte Spp1 mRNA and OPN secretion induced by hepatocyte-specific CEBPA knockout contributes to enhanced HSC activation, hepatocytes from Cebpa Hep or Cebpa fl/fl mice were transfected with control or Spp1 shRNA in the presence of palmitic acid