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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

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The Wilks' Lambda and squared Mahalanobis distances statistics were used to evaluate the significance in group separation (44,46)

The nonlytic release of -coronavirus triggers lysosomal deacidification, inactivation of lysosomal degrading enzymes, and interruption of antigen presentation pathways

5d) and increased fluorescence of the acs-2 p::GFP reporter by 68% (Supplementary Fig

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