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Tail-vein injection of parental, control and Grpr -expressing cells demonstrated that GRPR expression alone is sufficient to promote lung metastasis (Fig

however, once the balance between ROS production and clearance is disrupted, excessive ROS generation can lead to heightened oxidative stress (17)

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70 In addition, substance P accelerates inflammatory signaling and is of considerable research interest in chronic pain as well as psychological conditions including depression, anxiety, and PTSD

Remember that the inflammasome is a multimeric protein complex that senses harm or harm-associated molecular patterns (DAMPs) and serves as a major platform for caspase-1 activation and the maturation of the proinflammatory cytokine IL-1beta