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Serious adverse events are rare, but persistent GI distress or severe allergic reactions warrant immediate discontinuation and consultation with a supervising researcher or physician

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Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate

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Data from a review of patient experiences and surveys involving more than 2200 patients with B12 deficiency in the UK indicate that many patients have concerns related to healthcare quality, safety, and treatment, with nearly two-thirds of respondents reporting that their treatment is insufficient to manage symptoms