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Systemic absorption for muscle tissue remains lower when taking capsules compared to direct injections

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10.1371/journal.pone.0131882 [DOI] [PMC free article] [PubMed] [Google Scholar] di Giacomo V., Ferrante C., Ronci M., Cataldi A., Di Valerio V., Rapino M., et al

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Niacin (100 mg/day in dogs) may also lower hypertriglyceridemia by decreasing the production of VLDL and the release of fatty acids from adipocytes (113, 114) ( Table 2 )

One would be to do several RCTs within a country to take account of different contexts and use qualitative studies to tease out causal processes for what works and what doesnt