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Both deamination of Gln and degradation of GSH by Helicobacter GGT generate glutamate 15,16,20 , which can be taken up in the bacterial cell by a Na + -dependent transporter 20,29

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This mechanism holds the highest translational value due to consistent human data and well-defined molecular targets [e.g., competition with arachidonic acid for COX/LOX enzymes (84)]

Among these proteins, SMOC1 was identified as a central hub with significant RNA-dependent expression characteristics, validated in two independent cohorts