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DNA-TG was able to predict leukopenia in wild-type patients and patients with TPMT/NUDT15 variants

10.1016/j.neuroscience.2008.09.058 108 WangC

The findings are summarized in Table 2

Goenjian AK, Yehuda R, Pynoos RS, Steinberg AM, Tashjian M, Yang RK et al (1996)

Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models

Recent findings demonstrating the key role of fatty acid oxidation for renal cell proliferation and compensatory hypertrophy may help to understand the complex mechanisms involved in this process and whether abnormal lipid metabolism in the injured kidney may contribute to IGF-1 resistance