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Description

The unrestricted pathway, due to epithelial cell damage, is independent of TJs and allows for the pathologic flux of luminal content across the epithelium

Some practitioners suggest cycling, with a 6-12 week usage period followed by a 4-8 week break between cycles

Science of the Total Environment, 801: 149709 Mandal A, Sinha C, Jena A K, Ghosh S, Samanta A (2010)

Beyond airway cells and bacterial interactions, DHE-based investigations have indicated increased general intracellular superoxide in the pancreas of CF pigs, a finding linked to endothelial dysfunction within the CF context (OMalley et al., 2022)