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77 By integrating HIF-1, -catenin, and SREBP-dependent transcriptional programs, LPA signaling converges on dual reprogramming of glycolysis and lipogenesis, enabling tumors to adapt, grow, and resist therapy under metabolic constraints

Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, et al

Because of its extended half-life, Cagrilintide only requires a once-weekly injection

Ferroptosis is a metabolic vulnerability of tumor-specific CD8+ T cells, whereas GPX4-deficient T cells display a high sensitivity to ferroptosis and are thus incapable of exerting antitumor effects

10.1016/j.neuint.2020.104815 166 ZhangX

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