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An increase in ROS levels has been demonstrated to be crucial to inducing and maintaining senescence process (Davalli et al., 2016)

doi: 10.3346/jkms.2015.30.10.1429 60 RajNSLavanyaPRaviM

(2017), shows that certain therapy-resistant cancer cells or those with loss of certain tumour suppressors (such as BRCA1 ) are vulnerable to ferroptosis

As part of the flavone subgroup, it is formed by many components, here it is described the action of apigenin, baicalein, baicalin, wogonoside, wogonin, luteolin, tangeretin, galangin, nobiletin, and chrysin

Other than IDO, cancer cells can also use TDO, an immunosuppressive enzyme, to avoid immune destruction

Hypoxia increases the deoxycytidine triphosphate (dCTP) level through the pentose phosphate pathway (PPP) via glucose metabolism and results in resistance to gemcitabine, a dCTP analog 87