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Its a research tool with a fascinating history and an ongoing role in laboratory discovery

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Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials

Glucose-Dependent Insulinotropic Polypeptide (GIP), is a 42-amino acid peptide, produced by K-cells in the duodenum and jejunum and released into the general circulation upon stimulation by dietary lipids (147)

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In some cases, injections are paused to monitor natural absorption or due to changing medical needs, not because B12 is unsafe