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126,127 Familial genetic mutations and polymorphisms can also alter astrocyte functions in ways that contribute to disorder progression as noted in Huntingtons disease, 117,128 familial amyotrophic lateral sclerosis (ALS) mutations, 129,130 or familial AD mutations

FDA drug safety communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection

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4 The major clinical criteria of clEDS are (1) skin hyperextensibility, with velvety skin texture and absence of atrophic scarring

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Monitoring: Clinical response assessment rather than routine serum B12 measurement, as levels remain elevated following injection regardless of tissue adequacy