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Buzzetti E, Pinzani M, Tsochatzis EA (2016) The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

A pair of transporters controls mitochondrial Zn(2+) levels to maintain mitochondrial homeostasis

Higher doses should be short-term and taken under professional guidance

2020), which are a second signal for NLRP3 inflammasome activation and subsequent IL-1 release by decreasing calcium efflux (Table 6, Fig

Remarkably, nuclear receptor coactivator 4 (NCOA4), a key cytosolic autophagy receptor responsible for initiating ferritinophagy, mediates the degradation of ferritin, which subsequently increases intracellular Fe 2+ levels and lipid peroxidation, ultimately leading to ferroptosis [206, 207]