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This is a major gap in the research, leaving huge unanswered questions about its safety, side effects, and proper dosage

It is crucial to protect the lyophilized powder from direct light exposure to prevent degradation

When an individual has an MTHFR polymorphism, their body struggles to efficiently convert synthetic cyanocobalamin (the cheap form of B12 found in most standard supplements and fortified foods) into the active methylcobalamin required by the cells

For the maintenance treatment of vitamin B12 deficiency, the usual dose is 100mcg SC/IM, given once per month

Lot-specific COAs should be followed, and stability confirmed by standard QC (e.g., HPLC) [6,7]

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