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Then they tested the synergistic effect of these two compounds, and interestingly, they showed promising results on the modulation and opening of Kv channels isoform KCNQ25, and the activation of these channels is of critical importance in the control of seizure, action potential, and repolarization

Two reviewers (JF and JJ) independently screened the eligibility based on abstracts and titles

Kong et al., 2023)

Moreover, topiramate, an anti-epileptic drug that provides neuroprotection by preventing glutamate toxicity, has antidiabetic and beta-cell cytoprotective effects [129] and long-lasting remission was observed in a T1D patient after treatment with topiramate for generalized seizures [130]

The once widely accepted primary role for -amyloid in sporadic AD (known as the amyloid cascade hypothesis) is currently criticised as not being the sole cause of AD, but nevertheless, amyloid accumulation is clearly a part of AD pathology and evokes multifaceted glial responses

R., Huggett A