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ALOX5 inhibitors-zileuton, MK-886, BWA4C, and PD146176-exert anti-ferroptotic effects [71,72,73]

Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH, et al

observed that PD monocytes displayed increased absolute ROS levels and ROS normalized to mitochondrial content, but PBMCs as a whole did not show significant differences [30]

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Future rigorous clinical trials are required to clarify its efficacy specificity, address long-term safety concerns in the PD population, and evaluate its potential cost-effectiveness advantages