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These pathological sequelae are associated with hippocampal neuronal damage and memory loss (Fig

Cui L, Liu X, Yan R, et al

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Innate Repair Receptor (IRR) Activation: ARA-290 binds selectively to the IRR (EPOR/CR heteromer), activating the full IRR-mediated tissue protection cascade: JAK2/STAT3, PI3K/Akt, and MAPK/ERK signalling, producing anti-apoptotic, anti-inflammatory, and regenerative downstream effects across neural, vascular, and metabolic cell types

In addition, several C 30 H 48 O 4 , C 30 H 48 O 5 , and C 30 H 48 O 6 triterpenoids, as well as their derivatives acylated with coumaric, ferulic, or caffeic acid, were tentatively identified by LC-HRMS in extracts from SB fruit, twigs, and leaves (Marciniak et al

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