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A recent study on mice demonstrated that maternal obesity induced sex-specific alterations in the repressive histone mark H3K9me3 in offspring livers, which were accompanied by marked malefemale differences in gene expression, particularly in metabolic and stress-response pathways [150]

This subsequently increased the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAC), which is required for the N-glycosylation of many cell surface proteins expressed on M2 Ms (10), how they regulate the extent of inflammation by coregulating inflammatory and anti-inflammatory pathways remain unclear

sulindac, a NSAID, which inhibits COX-2 [54] and the anti-diabetic drug pioglitazone, which is an agonist of the peroxisome proliferator-activated receptor gamma with anti-inflammatory effects [55, 56]

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Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients