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Extrinsic regulation of oligodendrocyte responses OL responses are regulated by extrinsic influences throughout the lifespan, including in response to CNS injury

In the presence of another reductant, Compound II will return to the resting state (Glorieux and Calderon 2017)

Annu Rev Immunol (2014) 32:659702

These complexes detect danger signals such as PAMPs and DAMPs, leading to the activation of caspase-1 and the maturation of pro-inflammatory cytokines IL-1 and IL-18

Legrand O, Perrot JY, Tang R, Simonin G, Gurbuxani S, Zittoun R, Marie JP

A path to translation: How 3D patient tumor avatars enable next generation precision oncology