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Evidence (excision): A randomized trial that compared narrow margins (1 cm) with wide margins (3 cm) in 612 patients with melanomas no thicker than 2 mm included 359 patients with melanomas measuring 1 mm or less.[1,2][Level of evidence A1] No difference was observed between the two groups in the development of metastatic disease, disease-free survival (DFS), or overall survival (OS)

How is PT-141 Administered

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Its mechanism involves modulation of melanocortin receptors, which are associated with regulatory processes in the brain

Increased blood pressure Though PT-141 does not directly affect blood vessels, a minority of users have experienced a temporary rise in blood pressure

Clinical trials employing ambulatory blood pressure monitoring documented small, transient increases in systolic blood pressure (2-3 mmHg) and reductions in heart rate occurring 0-4 hours post-dose