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In response to systemic inflammation, and in particular in response to elevated IL-6 levels, the liver produces (C-reactive protein) CRP, a protein that binds to dead or dying cells to activate the complement system

Infection and autoimmunity in Sjogrens syndrome: a clinical study and comprehensive review

Harden JL, Krueger JG, Bowcock AM

Cancer Res 2014;74:2295-305

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23 This is especially important in the brain and airways, where HNMT is the primary clearance pathway