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Rather than treating ferroptosis as a uniform vulnerability, clinical translation will probably succeed where patients can be stratified by (1) the architecture of antioxidant defenses (for example, FSP1/GPX4 balance), (2) the size and distribution of cellular CoQ pools, (3) lipid composition and peroxidation-prone membranes and (4) oncogenic programs that remodel redox metabolism (such as NRF2KEAP1)

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Months 7 through 12 (maintenance dose) Weight loss: 35 to 55+ pounds total

10.1016/S0006-8993(02)03674-0 Brain Res

In many other cases, the affected individual may present with no signs, symptoms, and with no typical lab values in the early stage of this disease (Mincer & Jialal, 2019)

Surprisingly, some mice were also observed to alleviate the shortening with low concentrations such as 0.025%