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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

Cabral DJ, Penumutchu S, Norris C, Morones-Ramirez JR, Belenky P

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Effect of pycnogenol on glucose transport in mature 3T3-L1 adipocytes

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High levels of TSH promote the growth and activity of thyrocytes which may result in the enlargement of the thyroid gland known as goiter