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8 Future challenges and directions Although numerous studies have demonstrated the potential of IGF-1 in advancing tendon treatment strategies, significant challenges remain in developing an effective IGF-1-based therapy for tendon regenerative healing

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GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

V-9302 inhibited Gln uptake by ASCT2 cells, leading to attenuated growth and proliferation, increased apoptosis, and increased oxidative stress in CRC cells [56]

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