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Following terminal sacrifice 5 days after the last administration, gross necropsy, measurement of organ weights and histopathologic examinations were conducted

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Unlike the mice with diet-induced MASH that demonstrated hepatic oxalate overproduction due to suppressed AGXT and enhanced LDHA activity, overexpression of AGXT or treatment with MDMG-935P in mice fed the standard chow diet had no significant effects on liver oxalate, indices of liver damage or lipid metabolism

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics